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An ingestible self-orienting system for oral delivery of macromolecules.
Abramson, Alex; Caffarel-Salvador, Ester; Khang, Minsoo; Dellal, David; Silverstein, David; Gao, Yuan; Frederiksen, Morten Revsgaard; Vegge, Andreas; Hubálek, Frantisek; Water, Jorrit J; Friderichsen, Anders V; Fels, Johannes; Kirk, Rikke Kaae; Cleveland, Cody; Collins, Joy; Tamang, Siddartha; Hayward, Alison; Landh, Tomas; Buckley, Stephen T; Roxhed, Niclas; Rahbek, Ulrik; Langer, Robert; Traverso, Giovanni.
Affiliation
  • Abramson A; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Caffarel-Salvador E; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Khang M; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Dellal D; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Silverstein D; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Gao Y; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Frederiksen MR; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Vegge A; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Hubálek F; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Water JJ; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Friderichsen AV; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Fels J; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Kirk RK; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Cleveland C; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Collins J; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Tamang S; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Hayward A; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Landh T; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Buckley ST; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Roxhed N; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Rahbek U; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Langer R; Global Research Technologies, Global Drug Discovery, and Device R&D, Novo Nordisk A/S, Copenhagen, Denmark.
  • Traverso G; Department of Chemical Engineering and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science ; 363(6427): 611-615, 2019 02 08.
Article in En | MEDLINE | ID: mdl-30733413
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Administration, Oral / Drug Delivery Systems / Macromolecular Substances / Insulin Limits: Animals Language: En Journal: Science Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Administration, Oral / Drug Delivery Systems / Macromolecular Substances / Insulin Limits: Animals Language: En Journal: Science Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States