Age-dependent changes and biomarkers of aging in Caenorhabditis elegans.
Aging Cell
; 18(2): e12853, 2019 04.
Article
in En
| MEDLINE
| ID: mdl-30734981
ABSTRACT
Caenorhabditis elegans is an exceptionally valuable model for aging research because of many advantages, including its genetic tractability, short lifespan, and clear age-dependent physiological changes. Aged C. elegans display a decline in their anatomical and functional features, including tissue integrity, motility, learning and memory, and immunity. Caenorhabditis elegans also exhibit many age-associated changes in the expression of microRNAs and stress-responsive genes and in RNA and protein quality control systems. Many of these age-associated changes provide information on the health of the animals and serve as valuable biomarkers for aging research. Here, we review the age-dependent changes in C. elegans and their utility as aging biomarkers indicative of the physiological status of aging.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Caenorhabditis elegans
Limits:
Animals
Language:
En
Journal:
Aging Cell
Year:
2019
Document type:
Article
Affiliation country:
South Korea