Identification of molecular targets for toxic action by persulfate, an industrial sulfur compound.

Shimada, Takahisa; Takahashi, Kenji; Tominaga, Makoto; Ohta, Toshio

Shimada, Takahisa; Takahashi, Kenji; Tominaga, Makoto; Ohta, Toshio.

Affiliation

Shimada T; Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori, Japan.
Takahashi K; Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori, Japan.
Tominaga M; Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Okazaki, Japan.
Ohta T; Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori, Japan. Electronic address: tohta@muses.tottori-u.ac.jp.

Neurotoxicology ; 72: 29-37, 2019 05.

Article in En | MEDLINE | ID: mdl-30738091

Subject(s)

Neurons/drug effects; Neurons/metabolism; Sulfur Compounds/toxicity; Sulfur/toxicity; TRPA1 Cation Channel/metabolism; TRPV Cation Channels/metabolism; Calcium/metabolism; Environmental Pollutants/toxicity; Ganglia, Spinal/drug effects; Ganglia, Spinal/metabolism; HEK293 Cells; Humans; TRPA1 Cation Channel/agonists; TRPA1 Cation Channel/antagonists & inhibitors

Key words

Dorsal root ganglia; Heterologous expression; Intracellular Ca(2+); Ion channel; Sensory neuron; TRPA1; TRPV1; Transient Receptor Potential (TRP)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfur / Sulfur Compounds / TRPV Cation Channels / TRPA1 Cation Channel / Neurons Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Neurotoxicology Year: 2019 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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