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Development of a remote purification apparatus with disposable evaporator for the routine production of high-quality 64Cu for clinical use.
Ohya, Tomoyuki; Minegishi, Katsuyuki; Suzuki, Hisashi; Nagatsu, Kotaro; Fukada, Masami; Hanyu, Masayuki; Zhang, Ming-Rong.
Affiliation
  • Ohya T; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan. Electronic address: ohya.tomoyuki@qst.go.jp.
  • Minegishi K; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
  • Suzuki H; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
  • Nagatsu K; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
  • Fukada M; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
  • Hanyu M; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
  • Zhang MR; National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
Appl Radiat Isot ; 146: 127-132, 2019 Apr.
Article in En | MEDLINE | ID: mdl-30769173
ABSTRACT
We developed a new apparatus for the routine production of 64Cu in clinical use. The apparatus has many disposable parts that stabilize the product quality (such that there is a low deviation of the concentrations of impurity metals in the product) and reduce the work load of preparation for routine production. We also developed a new evaporator using near-infrared heaters for disposable use. We conducted a production test using the new apparatus and evaluated product quality. The product yield was 6.3 ±â€¯0.32 GBq (end of bombardment) (N = 4), the product quality in terms of the concentrations of impurity metals (Cu2+, Ni2+, Fe3+, Zn2+, Mn2+) was as good as that usually achieved, likely on the order of parts per billion, and the preparation time was reduced from 2 days to 1 day.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Copper Radioisotopes / Technology, Radiologic / Radiopharmaceuticals Limits: Humans Language: En Journal: Appl Radiat Isot Journal subject: MEDICINA NUCLEAR / SAUDE AMBIENTAL Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Copper Radioisotopes / Technology, Radiologic / Radiopharmaceuticals Limits: Humans Language: En Journal: Appl Radiat Isot Journal subject: MEDICINA NUCLEAR / SAUDE AMBIENTAL Year: 2019 Document type: Article