Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer's disease.

Ragab, Hanan M; Teleb, Mohamed; Haidar, Hassan R; Gouda, Noha

Ragab, Hanan M; Teleb, Mohamed; Haidar, Hassan R; Gouda, Noha.

Affiliation

Ragab HM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt. Electronic address: tafida12@yahoo.com.
Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Haidar HR; Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon.
Gouda N; Noha Gouda, Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.

Bioorg Chem ; 86: 557-568, 2019 05.

Article in En | MEDLINE | ID: mdl-30782574

Subject(s)

Acetylcholinesterase/metabolism; Alzheimer Disease/drug therapy; Cholinesterase Inhibitors/pharmacology; Tacrine/pharmacology; Alzheimer Disease/metabolism; Animals; Anura; Cholinesterase Inhibitors/chemical synthesis; Cholinesterase Inhibitors/chemistry; Dose-Response Relationship, Drug; Halogenation; Humans; Liver/drug effects; Liver/metabolism; Male; Molecular Docking Simulation; Molecular Structure; Rats; Structure-Activity Relationship; Tacrine/chemical synthesis; Tacrine/chemistry

Key words

Alzheimer's disease; Anti-cholinesterase activity; Chlorinated phenyl tetrahydroquinolines; Hepatotoxicity; Tacrine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcholinesterase / Tacrine / Cholinesterase Inhibitors / Alzheimer Disease Limits: Animals / Humans / Male Language: En Journal: Bioorg Chem Year: 2019 Document type: Article Country of publication: United States

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