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Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes.
Follo, Matilde Y; Pellagatti, Andrea; Armstrong, Richard N; Ratti, Stefano; Mongiorgi, Sara; De Fanti, Sara; Bochicchio, Maria Teresa; Russo, Domenico; Gobbi, Marco; Miglino, Maurizio; Parisi, Sarah; Martinelli, Giovanni; Cavo, Michele; Luiselli, Donata; McCubrey, James A; Suh, Pann-Ghill; Manzoli, Lucia; Boultwood, Jacqueline; Finelli, Carlo; Cocco, Lucio.
Affiliation
  • Follo MY; Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. matilde.follo@unibo.it.
  • Pellagatti A; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK.
  • Armstrong RN; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK.
  • Ratti S; Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Mongiorgi S; Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • De Fanti S; Department of Biological, Geological, and Environmental Sciences, University of Bologna, Bologna, Italy.
  • Bochicchio MT; Department of Hematology "L e A Seràgnoli", University of Bologna, Bologna, Italy.
  • Russo D; Chair of Hematology, Unit of Blood Disease and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Gobbi M; Department of Hematology and Oncology, University of Genova, Genova, Italy.
  • Miglino M; Department of Hematology and Oncology, University of Genova, Genova, Italy.
  • Parisi S; Department of Hematology "L e A Seràgnoli", University of Bologna, Bologna, Italy.
  • Martinelli G; Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
  • Cavo M; Department of Hematology "L e A Seràgnoli", University of Bologna, Bologna, Italy.
  • Luiselli D; Department of Cultural Heritage, University of Bologna, Ravenna, Italy.
  • McCubrey JA; Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.
  • Suh PG; School of Life Sciences, UNIST, Ulsan, Republic of Korea.
  • Manzoli L; Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Boultwood J; Bloodwise Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, and Oxford BRC Haematology Theme, Oxford, UK.
  • Finelli C; Department of Hematology "L e A Seràgnoli", University of Bologna, Bologna, Italy.
  • Cocco L; Cellular Signalling Laboratory, Human Anatomy Section, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. lucio.cocco@unibo.it.
Leukemia ; 33(9): 2276-2290, 2019 09.
Article in En | MEDLINE | ID: mdl-30787430
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Myelodysplastic Syndromes / Lenalidomide / Inositol / Mutation Type of study: Etiology_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2019 Document type: Article Affiliation country: Italy
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azacitidine / Myelodysplastic Syndromes / Lenalidomide / Inositol / Mutation Type of study: Etiology_studies / Risk_factors_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2019 Document type: Article Affiliation country: Italy