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Sesquiterpenes from the Leaves of Magnolia delavayi Franch. and Their Cytotoxic Activities.
Xie, Zhang-Qiao; Ding, Lin-Fen; Wang, De-Sheng; Nie, Wei; Liu, Jiang-Xin; Qin, Jing; Song, Liu-Dong; Wu, Xing-De; Zhao, Qin-Shi.
Affiliation
  • Xie ZQ; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, P. R. China.
  • Ding LF; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Wang DS; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, P. R. China.
  • Nie W; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, P. R. China.
  • Liu JX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Qin J; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, P. R. China.
  • Song LD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Wu XD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
  • Zhao QS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
Chem Biodivers ; 16(5): e1900013, 2019 May.
Article in En | MEDLINE | ID: mdl-30811806
Thirteen sesquiterpenes including eight new ones, magnodelavins A-H (1-8), were obtained from the 95 % ethanolic extract of the leaves of Magnolia delavayi Franch. The structures of the new compounds were determined by exhaustive 1 H-, 13 C-, 2D-NMR, UV, IR, and HR-ESI-MS data, as well as X-ray crystallographic analysis. Compounds 9 and 10 showed potent cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, and SW480 human cancer cell lines in vitro using MTS assay.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Magnolia / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Magnolia / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: Switzerland