Leptin receptor deficiency induces early, transient and hyperglycaemia-independent blood-brain barrier dysfunction.

Corem, Noa; Anzi, Shira; Gelb, Sivan; Ben-Zvi, Ayal

Corem, Noa; Anzi, Shira; Gelb, Sivan; Ben-Zvi, Ayal.

Affiliation

Corem N; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
Anzi S; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
Gelb S; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, 91120, Israel.
Ben-Zvi A; Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, 91120, Israel. Ayalb@ekmd.huji.ac.il.

Sci Rep ; 9(1): 2884, 2019 02 27.

Article in En | MEDLINE | ID: mdl-30814586

Subject(s)

Blood-Brain Barrier/pathology; Diabetes Mellitus, Experimental/physiopathology; Disease Models, Animal; Hyperglycemia/physiopathology; Obesity/physiopathology; Receptors, Leptin/physiology; Animals; Blood-Brain Barrier/metabolism; Capillary Permeability; Female; Male; Mice; Mice, Knockout

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Diabetes Mellitus, Experimental / Disease Models, Animal / Receptors, Leptin / Hyperglycemia / Obesity Limits: Animals Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Israel Country of publication: United kingdom

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