EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease.

Zeng, Xue; Hunt, Ava; Jin, Sheng Chih; Duran, Daniel; Gaillard, Jonathan; Kahle, Kristopher T

Zeng, Xue; Hunt, Ava; Jin, Sheng Chih; Duran, Daniel; Gaillard, Jonathan; Kahle, Kristopher T.

Affiliation

Zeng X; Department of Genetics, Yale School of Medicine, New Haven CT, USA; Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.
Hunt A; Department of Neurosurgery, Yale School of Medicine, New Haven CT, USA.
Jin SC; Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.
Duran D; Department of Neurosurgery, Yale School of Medicine, New Haven CT, USA.
Gaillard J; Department of Neurosurgery, Yale School of Medicine, New Haven CT, USA.
Kahle KT; Department of Neurosurgery, Yale School of Medicine, New Haven CT, USA; Department of Pediatrics, Yale School of Medicine, New Haven CT, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven CT, USA. Electronic address: kristopher.kahle@yale.edu.

Trends Mol Med ; 25(4): 265-286, 2019 04.

Article in En | MEDLINE | ID: mdl-30819650

Subject(s)

Cerebrovascular Disorders/etiology; Cerebrovascular Disorders/metabolism; Ephrin-B2/metabolism; Neovascularization, Physiologic; Receptor, EphB4/metabolism; Signal Transduction; p120 GTPase Activating Protein/metabolism; Animals; Cerebrovascular Disorders/pathology; Disease Susceptibility; Ephrin-B2/chemistry; Ephrin-B2/genetics; Genetic Predisposition to Disease; Humans; Receptor, EphB4/chemistry; Receptor, EphB4/genetics; Structure-Activity Relationship; p120 GTPase Activating Protein/chemistry; p120 GTPase Activating Protein/genetics

Key words

Vein of Galen malformation; arteriovenous malformation; cerebrovascular disorders; ephrin signaling; neurosurgery; vasculogenesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cerebrovascular Disorders / Neovascularization, Physiologic / P120 GTPase Activating Protein / Receptor, EphB4 / Ephrin-B2 Limits: Animals / Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: United States

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