Help from my friends-cooperation of BMAL1 with noncircadian transcription factors.
Genes Dev
; 33(5-6): 255-257, 2019 03 01.
Article
in En
| MEDLINE
| ID: mdl-30824531
ABSTRACT
The circadian clock in the suprachiasmatic nucleus (SCN) of mammals drives 24-h rhythms of sleep/wake cycles. Peripheral clocks present in other organs coordinate local and global physiology according to rhythmic signals from the SCN and via metabolic cues. The core circadian clockwork is identical in all cells. However, there is only a small amount of overlap of the circadian transcriptomes in different organs and tissues. A novel study by Beytebiere and colleagues (pp. 294-309) indicates that the regulation of tissue-specific rhythmic gene expression involves the cooperation of the circadian transcription factor (TF) BMAL1CLOCK with tissue-specific TFs (ts-TFs) and correlates with the potential of BMAL1CLOCK to facilitate rhythmic enhancer-enhancer interactions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CLOCK Proteins
/
Circadian Clocks
Limits:
Animals
Language:
En
Journal:
Genes Dev
Journal subject:
BIOLOGIA MOLECULAR
Year:
2019
Document type:
Article
Affiliation country:
Germany