Epigenetic therapy can inhibit growth of ovarian cancer cells and reverse chemoresistant properties acquired from metastatic omentum.

Sookram, Janhvi; Zheng, Andrew; Linden, Kimberly M; Morgan, Andrew B; Brown, Spencer A; Ostrovsky, Olga

Sookram, Janhvi; Zheng, Andrew; Linden, Kimberly M; Morgan, Andrew B; Brown, Spencer A; Ostrovsky, Olga.

Affiliation

Sookram J; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cooper University Hospital, Camden, NJ, USA.
Zheng A; Department of Surgery, Cooper University Hospital, Camden, NJ, USA.
Linden KM; Department of Surgery, Cooper University Hospital, Camden, NJ, USA.
Morgan AB; Department of Surgery, Cooper University Hospital, Camden, NJ, USA.
Brown SA; Department of Surgical Research, Cooper University Hospital, Camden, NJ, USA.
Ostrovsky O; Department of Surgical Research, Cooper University Hospital, Camden, NJ, USA.

Int J Gynaecol Obstet ; 145(2): 225-232, 2019 May.

Article in En | MEDLINE | ID: mdl-30828803

Subject(s)

Cisplatin/pharmacology; Drug Resistance, Neoplasm; Ovarian Neoplasms/drug therapy; Paclitaxel/pharmacology; Uterine Neoplasms/drug therapy; Antineoplastic Agents/therapeutic use; Cell Line, Tumor/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Humans; Omentum; Pilot Projects

Key words

Adipose-derived stem cells; Chemoresistance; Chemotherapy; Conditioned medium; Epigenetic drugs; Omental microenvironment; Omentum; Ovarian cancer; Secretome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Uterine Neoplasms / Cisplatin / Paclitaxel / Drug Resistance, Neoplasm Limits: Female / Humans Language: En Journal: Int J Gynaecol Obstet Year: 2019 Document type: Article Affiliation country: United States Country of publication: United States

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