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Oxidative DNA Damage-Mediated Genomic Heterogeneity Is Regulated by NKX3.1 in Prostate Cancer.
Debelec-Butuner, Bilge; Bostanci, Aykut; Ozcan, Filiz; Singin, Oznur; Karamil, Selda; Aslan, Mutay; Roggenbuck, Dirk; Korkmaz, Kemal Sami.
Affiliation
  • Debelec-Butuner B; a Department of Pharmaceutical Biotechnology, Faculty of Pharmacy , Ege University , Izmir , Turkey.
  • Bostanci A; b Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering , Ege University , Izmir , Turkey.
  • Ozcan F; c Mass Spectrometry Laboratory, Department of Biochemistry, Faculty of Medicine , Akdeniz University , Antalya , Turkey.
  • Singin O; b Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering , Ege University , Izmir , Turkey.
  • Karamil S; b Department of Bioengineering, Cancer Biology Laboratory, Faculty of Engineering , Ege University , Izmir , Turkey.
  • Aslan M; c Mass Spectrometry Laboratory, Department of Biochemistry, Faculty of Medicine , Akdeniz University , Antalya , Turkey.
  • Roggenbuck D; d Medipan GmBH , Dahlewitz , Germany.
  • Korkmaz KS; e Faculty Environment and Natural Sciences , Brandenburg University of Technology Cottbus-Senftenberg , Senftenberg , Germany.
Cancer Invest ; 37(2): 113-126, 2019.
Article in En | MEDLINE | ID: mdl-30836777
The 8-hydroxy-2'-deoxyguanosine (8-OHdG) damages are base damages induced by reactive oxygen species. We aimed to investigate the role of Androgen Receptor and NKX3.1 in 8-OHdG formation and repair activation by quantitating the DNA damage using Aklides.NUK system. The data demonstrated that the loss of NKX3.1 resulted in increased oxidative DNA damage and its overexpression contributes to the removal of menadione-induced 8-OHdG damage even under oxidative stress conditions. Moreover, 8-oxoguanine DNA glycosylase-1 (OGG1) expression level positively correlates to NKX3.1 expression. Also in this study, first time a reliable cell-based quantitation method for 8-OHdG damages is reported and used for data collection.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Transcription Factors / DNA Damage / Oxidative Stress / Homeodomain Proteins Limits: Humans / Male Language: En Journal: Cancer Invest Year: 2019 Document type: Article Affiliation country: Turkey Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Transcription Factors / DNA Damage / Oxidative Stress / Homeodomain Proteins Limits: Humans / Male Language: En Journal: Cancer Invest Year: 2019 Document type: Article Affiliation country: Turkey Country of publication: United kingdom