Antitumor activity on human bladder cancer T-24 cells and composition analysis of the core of Camellia osmantha fruit.
Nat Prod Res
; 34(18): 2689-2693, 2020 Sep.
Article
in En
| MEDLINE
| ID: mdl-30856009
ABSTRACT
In this study, antitumor activity and composition analysis of the core of Camellia osmantha fruit were investigated. The cores were extracted by 80% ethanol to obtain the crude extract (TF), which was successively distributed by different concentrations of ethanol with MCI resin to obtain three different parts (Frs 1 to 3). Cytotoxicity activities showed that TF, Fr-2, and Fr-3 exhibited good inhibition against T-24 with IC50 values of 6.7 ± 1.3, 6.9 ± 0.9, and 6.7 ± 1.7 µg/mL, respectively. Fr-3 has a strong inhibitory activity on T-24 cells, mainly due to effectively increasing the release of intracellular calcium ions and reactive oxygen species. In addition, Fr-3 can inhibit T-24 cells migration and invasion. Further composition analysis on Fr-3 was detected by LC-Q-TOFMS implying the main components to be ellagic acid and its derivatives.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urinary Bladder Neoplasms
/
Camellia
/
Fruit
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Nat Prod Res
Year:
2020
Document type:
Article
Affiliation country:
China