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(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.
Zanos, Panos; Highland, Jaclyn N; Stewart, Brent W; Georgiou, Polymnia; Jenne, Carleigh E; Lovett, Jacqueline; Morris, Patrick J; Thomas, Craig J; Moaddel, Ruin; Zarate, Carlos A; Gould, Todd D.
Affiliation
  • Zanos P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Highland JN; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Stewart BW; Program in Toxicology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Georgiou P; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Jenne CE; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Lovett J; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Morris PJ; Biomedical Research Center, National Institute on Aging, NIH, Baltimore, MD 21224.
  • Thomas CJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20892.
  • Moaddel R; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20892.
  • Zarate CA; Biomedical Research Center, National Institute on Aging, NIH, Baltimore, MD 21224.
  • Gould TD; Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892.
Proc Natl Acad Sci U S A ; 116(13): 6441-6450, 2019 03 26.
Article in En | MEDLINE | ID: mdl-30867285
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Depression / Ketamine / Antidepressive Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Depression / Ketamine / Antidepressive Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article Country of publication: United States