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Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.
Massaly, Nicolas; Copits, Bryan A; Wilson-Poe, Adrianne R; Hipólito, Lucia; Markovic, Tamara; Yoon, Hye Jean; Liu, Shiwei; Walicki, Marie C; Bhatti, Dionnet L; Sirohi, Sunil; Klaas, Amanda; Walker, Brendan M; Neve, Rachael; Cahill, Catherine M; Shoghi, Kooresh I; Gereau, Robert W; McCall, Jordan G; Al-Hasani, Ream; Bruchas, Michael R; Morón, Jose A.
Affiliation
  • Massaly N; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Copits BA; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Wilson-Poe AR; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Hipólito L; Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia 46100, Spain.
  • Markovic T; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Yoon HJ; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Liu S; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Walicki MC; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO 63110, USA; Center for Clinical Pharmacology, St.
  • Bhatti DL; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Sirohi S; Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA.
  • Klaas A; Department of Radiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA.
  • Walker BM; Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA.
  • Neve R; Department of Brain and Cognitive Science, Viral Gene Transfer Core, MIT, Cambridge, MA 02139-4307, USA.
  • Cahill CM; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Shoghi KI; Department of Radiology, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • Gereau RW; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA.
  • McCall JG; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO 63110, USA; Center for Clinical Pharmacology, St.
  • Al-Hasani R; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO 63110, USA; Center for Clinical Pharmacology, St.
  • Bruchas MR; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: mbruchas@uw.edu.
  • Morón JA; Department of Anesthesiology, Washington University Pain Center, Washington University in St. Louis, School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: jmoron-concepcion@wustl.edu.
Neuron ; 102(3): 564-573.e6, 2019 05 08.
Article in En | MEDLINE | ID: mdl-30878290
ABSTRACT
Negative affective states affect quality of life for patients suffering from pain. These maladaptive emotional states can lead to involuntary opioid overdose and many neuropsychiatric comorbidities. Uncovering the mechanisms responsible for pain-induced negative affect is critical in addressing these comorbid outcomes. The nucleus accumbens (NAc) shell, which integrates the aversive and rewarding valence of stimuli, exhibits plastic adaptations in the presence of pain. In discrete regions of the NAc, activation of the kappa opioid receptor (KOR) decreases the reinforcing properties of rewards and induces aversive behaviors. Using complementary techniques, we report that in vivo recruitment of NAc shell dynorphin neurons, acting through KOR, is necessary and sufficient to drive pain-induced negative affect. Taken together, our results provide evidence that pain-induced adaptations in the kappa opioid system within the NAc shell represent a functional target for therapeutic intervention that could circumvent pain-induced affective disorders. VIDEO ABSTRACT.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Dynorphins / Receptors, Opioid, kappa / Mood Disorders / Affect / Inflammation / Neurons / Nucleus Accumbens Type of study: Etiology_studies Aspects: Patient_preference Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Dynorphins / Receptors, Opioid, kappa / Mood Disorders / Affect / Inflammation / Neurons / Nucleus Accumbens Type of study: Etiology_studies Aspects: Patient_preference Limits: Animals Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country: United States