Non-invasive measurement of hemodynamic change during 8 MHz transcranial focused ultrasound stimulation using near-infrared spectroscopy.
BMC Neurosci
; 20(1): 12, 2019 Mar 18.
Article
in En
| MEDLINE
| ID: mdl-30885121
ABSTRACT
BACKGROUND:
Transcranial focused ultrasound (tFUS) attracts wide attention in neuroscience as an effective noninvasive approach to modulate brain circuits. In spite of this, the effects of tFUS on the brain is still unclear, and further investigation is needed. The present study proposes to use near-infrared spectroscopy (NIRS) to observe cerebral hemodynamic change caused by tFUS in a noninvasive manner.RESULTS:
The results show a transient increase of oxyhemoglobin and decrease of deoxyhemoglobin concentration in the mouse model induced by ultrasound stimulation of the somatosensory cortex with a frequency of 8 MHz but not in sham. In addition, the amplitude of hemodynamics change can be related to the peak intensity of the acoustic wave.CONCLUSION:
High frequency 8 MHz ultrasound was shown to induce hemodynamic changes measured using NIRS through the intact mouse head. The implementation of NIRS offers the possibility of investigating brain response noninvasively for different tFUS parameters through cerebral hemodynamic change.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Somatosensory Cortex
/
Ultrasonic Therapy
/
Spectroscopy, Near-Infrared
/
Hemodynamics
Limits:
Animals
Language:
En
Journal:
BMC Neurosci
Journal subject:
NEUROLOGIA
Year:
2019
Document type:
Article