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The 3D Genome: EZH2 Comes into the Fold.
Brien, Gerard L; Bracken, Adrian P.
Affiliation
  • Brien GL; Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland.
  • Bracken AP; Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland. Electronic address: BRACKEA@tcd.ie.
Trends Mol Med ; 25(5): 362-365, 2019 05.
Article in En | MEDLINE | ID: mdl-30885427
EZH2 is an oncogene in non-Hodgkin lymphoma. Understanding the underlying pathogenic mechanisms will be essential to improve treatments for patients with EZH2 mutant lymphomas. Recently Donaldson-Collier and colleagues (Nat. Genet. 2019; published online January 28, https://doi.org/10.1038/s41588-018-0338-y) examined the effects of mutant EZH2 on the 3D architecture of the lymphoma genome, highlighting the potential relevance of chromatin folding dynamics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, Non-Hodgkin / Genetic Predisposition to Disease / Genomics / Genome-Wide Association Study / Enhancer of Zeste Homolog 2 Protein / Mutation Limits: Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: Ireland Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, Non-Hodgkin / Genetic Predisposition to Disease / Genomics / Genome-Wide Association Study / Enhancer of Zeste Homolog 2 Protein / Mutation Limits: Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Document type: Article Affiliation country: Ireland Country of publication: United kingdom