Efficient hydrolytic cleavage of DNA and antiproliferative effect on human cancer cells by two dinuclear Cu(II) complexes containing a carbohydrazone ligand and 1,10-phenanthroline as a coligand.

Parsekar, Sidhali U; Singh, Manohar; Mishra, Durga P; Antharjanam, P K Sudhadevi; Koley, Aditya P; Kumar, Manjuri

Parsekar, Sidhali U; Singh, Manohar; Mishra, Durga P; Antharjanam, P K Sudhadevi; Koley, Aditya P; Kumar, Manjuri.

Affiliation

Parsekar SU; Department of Chemical Engineering, Birla Institute of Technology and Science-Pilani, K.K. Birla Goa Campus, Zuarinagar, Goa, 403726, India.
Singh M; Cell Death Research Laboratory, Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Mishra DP; Cell Death Research Laboratory, Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India.
Antharjanam PKS; Sophisticated Analytical Instrument Facility, Indian Institute of Technology-Madras, Chennai, 600036, India.
Koley AP; Department of Chemistry, Birla Institute of Technology and Science-Pilani, K.K. Birla Goa Campus, Zuarinagar, Goa, 403726, India. koleyap@yahoo.co.in.
Kumar M; Department of Chemical Engineering, Birla Institute of Technology and Science-Pilani, K.K. Birla Goa Campus, Zuarinagar, Goa, 403726, India. manjuri@goa.bits-pilani.ac.in.

J Biol Inorg Chem ; 24(3): 343-363, 2019 05.

Article in En | MEDLINE | ID: mdl-30887122

Subject(s)

Antineoplastic Agents/pharmacology; Coordination Complexes/pharmacology; DNA Cleavage/drug effects; DNA/drug effects; Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Cattle; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Coordination Complexes/chemical synthesis; Coordination Complexes/toxicity; Copper/chemistry; Crystallography, X-Ray; DNA/chemistry; G2 Phase Cell Cycle Checkpoints/drug effects; Humans; Hydrazones/chemical synthesis; Hydrazones/pharmacology; Hydrazones/toxicity; Intercalating Agents/chemical synthesis; Intercalating Agents/pharmacology; Intercalating Agents/toxicity; Ligands; Phenanthrolines/chemical synthesis; Phenanthrolines/pharmacology; Phenanthrolines/toxicity; Reactive Oxygen Species/metabolism

Key words

Cell cycle analysis; Cytotoxicity and anticancer activity; DNA binding and cleavage; Dinuclear Cu(II) complex; EPR and electronic spectra; MTT assay

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / DNA Cleavage / Coordination Complexes / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Biol Inorg Chem Journal subject: BIOQUIMICA Year: 2019 Document type: Article Affiliation country: India Country of publication: Germany

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