Evaluation of food effect on the oral absorption of clarithromycin from immediate release tablet using physiological modelling.

Radwan, Asma; Jayyousi, Rand; Shraim, Nasr; Zaid, Abdel Naser

Radwan, Asma; Jayyousi, Rand; Shraim, Nasr; Zaid, Abdel Naser.

Affiliation

Radwan A; College of Pharmacy, An-Najah National University, Nablus, Palestine.
Jayyousi R; College of Pharmacy, An-Najah National University, Nablus, Palestine.
Shraim N; College of Pharmacy, An-Najah National University, Nablus, Palestine.
Zaid AN; College of Pharmacy, An-Najah National University, Nablus, Palestine.

Biopharm Drug Dispos ; 40(3-4): 121-134, 2019 Apr.

Article in En | MEDLINE | ID: mdl-30891805

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Clarithromycin/pharmacokinetics; Food-Drug Interactions; Models, Biological; Administration, Oral; Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/chemistry; Clarithromycin/administration & dosage; Clarithromycin/chemistry; Computer Simulation; Drug Liberation; Fasting/metabolism; Gastric Juice/chemistry; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Secretions/chemistry; Solubility; Tablets

Key words

biorelevant media; clarithromycin; drug release; food effect; physiological modelling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Clarithromycin / Food-Drug Interactions / Anti-Bacterial Agents / Models, Biological Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biopharm Drug Dispos Year: 2019 Document type: Article Country of publication: United kingdom

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