Nonasaccharide Inhibits Intrinsic Factor Xase Complex by Binding to Factor IXa and Disrupting Factor IXa-Factor VIIIa Interactions.

Xiao, Chuang; Zhao, Longyan; Gao, Na; Wu, Mingyi; Zhao, Jinhua

Xiao, Chuang; Zhao, Longyan; Gao, Na; Wu, Mingyi; Zhao, Jinhua.

Affiliation

Xiao C; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Zhao L; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Gao N; School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.
Wu M; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Zhao J; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

Thromb Haemost ; 119(5): 705-715, 2019 May.

Article in En | MEDLINE | ID: mdl-30900221

Subject(s)

Cysteine Endopeptidases/metabolism; Neoplasm Proteins/metabolism; Oligosaccharides/pharmacology; Venous Thrombosis/drug therapy; Animals; Carbon Dioxide/chemistry; Disease Models, Animal; Factor IXa/metabolism; Factor X/metabolism; Heparin, Low-Molecular-Weight/therapeutic use; Humans; Kinetics; Magnetic Resonance Spectroscopy; Neoplasm Proteins/antagonists & inhibitors; Oligosaccharides/chemistry; Oligosaccharides/therapeutic use; Protein Binding; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligosaccharides / Cysteine Endopeptidases / Venous Thrombosis / Neoplasm Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Thromb Haemost Year: 2019 Document type: Article Affiliation country: China Country of publication: Germany

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