TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.

Huang, Yang Zhong; He, Xiao-Ping; Krishnamurthy, Kamesh; McNamara, James O

Huang, Yang Zhong; He, Xiao-Ping; Krishnamurthy, Kamesh; McNamara, James O.

Affiliation

Huang YZ; Departments of Neurobiology.
He XP; Departments of Neurobiology.
Krishnamurthy K; Departments of Neurobiology.
McNamara JO; Departments of Neurobiology, jmc@neuro.duke.edu.

J Neurosci ; 39(23): 4624-4630, 2019 06 05.

Article in En | MEDLINE | ID: mdl-30926745

Subject(s)

Hedgehog Proteins/metabolism; Hippocampus/metabolism; Membrane Glycoproteins/physiology; Nerve Tissue Proteins/physiology; Protein-Tyrosine Kinases/physiology; Sensory Receptor Cells/physiology; Status Epilepticus/metabolism; Animals; Binding Sites; Brain-Derived Neurotrophic Factor/pharmacology; Cell Differentiation/drug effects; Cell Survival/drug effects; Cells, Cultured; Hippocampus/pathology; MAP Kinase Signaling System/drug effects; Mechanotransduction, Cellular; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mutagenesis, Site-Directed; Nerve Growth Factors/pharmacology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Phosphorylation; Point Mutation; Protein Binding/genetics; Protein Processing, Post-Translational/drug effects; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Recombinant Proteins/metabolism; Sensory Receptor Cells/drug effects; Status Epilepticus/genetics; Touch/physiology

Key words

Shc; TrkB; hippocampus; neuroprotection; status epilepticus; temporal lobe epilepsy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sensory Receptor Cells / Status Epilepticus / Protein-Tyrosine Kinases / Membrane Glycoproteins / Hedgehog Proteins / Hippocampus / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Year: 2019 Document type: Article Country of publication: United States

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