Your browser doesn't support javascript.
loading
The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review.
Wang, Feng; Zhang, Quan-Bing; Zhou, Yun; Chen, Shuang; Huang, Peng-Peng; Liu, Yi; Xu, Yuan-Hong.
Affiliation
  • Wang F; Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
  • Zhang QB; Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
  • Zhou Y; Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, 230601, China. Electronic address: zhouyunanhui@sina.com.
  • Chen S; Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
  • Huang PP; Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
  • Liu Y; Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
  • Xu YH; Department of Clinical Laboratory, The First Hospital of Anhui Medical University, Hefei, 230601, China.
Chin J Traumatol ; 22(2): 93-98, 2019 Apr.
Article in En | MEDLINE | ID: mdl-30928194
The clinical treatment of joint contracture due to immobilization remains difficult. The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis. The proteolytic pathways involved in disuse muscle atrophy include the ubiquitin-proteasome-dependent pathway, caspase system pathway, matrix metalloproteinase pathway, Ca2+-dependent pathway and autophagy-lysosomal pathway. The important biological processes involved in skeletal muscle fibrosis include intermuscular connective tissue thickening caused by transforming growth factor-ß1 and an anaerobic environment within the skeletal muscle leading to the induction of hypoxia-inducible factor-1α. This article reviews the progress made in understanding the pathological processes involved in immobilization-induced muscle contracture and the currently available treatments. Understanding the mechanisms involved in immobilization-induced contracture of muscle tissue should facilitate the development of more effective treatment measures for the different mechanisms in the future.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Muscle, Skeletal / Contracture / Immobilization / Joints Type of study: Systematic_reviews Limits: Humans Language: En Journal: Chin J Traumatol Journal subject: TRAUMATOLOGIA Year: 2019 Document type: Article Affiliation country: China Country of publication: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Muscle, Skeletal / Contracture / Immobilization / Joints Type of study: Systematic_reviews Limits: Humans Language: En Journal: Chin J Traumatol Journal subject: TRAUMATOLOGIA Year: 2019 Document type: Article Affiliation country: China Country of publication: China