Safety and efficacy of treatment with lumacaftor in combination with ivacaftor in younger patients with cystic fibrosis.

Cheng, Pi Chun; Alexiou, Stamatia; Rubenstein, Ronald C

Cheng, Pi Chun; Alexiou, Stamatia; Rubenstein, Ronald C.

Affiliation

Cheng PC; a Division of Pulmonary Medicine and Cystic Fibrosis Center , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
Alexiou S; a Division of Pulmonary Medicine and Cystic Fibrosis Center , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
Rubenstein RC; a Division of Pulmonary Medicine and Cystic Fibrosis Center , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.

Expert Rev Respir Med ; 13(5): 417-423, 2019 05.

Article in En | MEDLINE | ID: mdl-30929526

Subject(s)

Aminophenols/therapeutic use; Aminopyridines/therapeutic use; Benzodioxoles/therapeutic use; Cystic Fibrosis/drug therapy; Quinolones/therapeutic use; Aminophenols/adverse effects; Aminopyridines/adverse effects; Benzodioxoles/adverse effects; Child; Child, Preschool; Clinical Trials as Topic; Cystic Fibrosis/genetics; Cystic Fibrosis Transmembrane Conductance Regulator/genetics; Drug Combinations; Humans; Mutation; Quinolones/adverse effects; Treatment Outcome

Key words

Cystic fibrosis; Orkambi; ivacaftor; lumacaftor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolones / Cystic Fibrosis / Benzodioxoles / Aminophenols / Aminopyridines Limits: Child / Child, preschool / Humans Language: En Journal: Expert Rev Respir Med Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom

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