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Cutaneous histopathology of the tick-bite region in severe fever with thrombocytopenia syndrome.
Sato, Takaoki; Nishida, Haruto; Goto, Mizuki; Sho, Yuriko; Yamate, Tomoko; Daa, Tsutomu; Yokoyama, Shigeo; Kurosawa, Keiko; Matsunari, Osamu; Sakamoto, Teruo; Matsumoto, Hiroyuki; Suzuki, Tadaki; Hasegawa, Hideki; Takeo, Naoko; Hatano, Yutaka.
Affiliation
  • Sato T; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Nishida H; Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Goto M; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Sho Y; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Yamate T; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Daa T; Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Yokoyama S; Department of Diagnostic Pathology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Kurosawa K; Department of Emergency Medicine, Faculty of Medicine, Oita University, Yufu, Japan.
  • Matsunari O; Department of Emergency Medicine, Faculty of Medicine, Oita University, Yufu, Japan.
  • Sakamoto T; Department of Emergency Medicine, Faculty of Medicine, Oita University, Yufu, Japan.
  • Matsumoto H; Department of Respiratory Medicine and Infectious diseases, Faculty of Medicine, Oita University, Yufu, Japan.
  • Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Hasegawa H; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
  • Takeo N; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Hatano Y; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.
J Dermatol ; 46(5): 409-412, 2019 May.
Article in En | MEDLINE | ID: mdl-30932227
ABSTRACT
A case of severe fever with thrombocytopenia syndrome (SFTS) in which a skin biopsy from the tick-bite region was analyzed is reported. The patient was a 72-year-old woman who developed fever and thrombocytopenia after a tick bite. SFTS was diagnosed from polymerase chain reaction (PCR) analysis of a blood sample. Histopathological analysis of a skin biopsy specimen from the tick-bite region showed CD20-positive perivascular and interstitial immunoblastic cells, which were positive to anti-SFTS virus (SFTSV) nucleoprotein antibody. In addition, SFTSV RNA was detected by real-time PCR from this biopsy specimen. Moreover, hemophagocytosis was also found in the tick-bite region. To the best of our knowledge, this is the first report to analyze the details of the tick-bite region of skin in SFTS, and the first to detect virus-infected cells in the skin. The present findings may help elucidate the mechanisms of entry of SFTSV.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombocytopenia / Phlebovirus / Phlebotomus Fever / Disseminated Intravascular Coagulation / Tick Bites Type of study: Diagnostic_studies Limits: Aged / Female / Humans Language: En Journal: J Dermatol Year: 2019 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombocytopenia / Phlebovirus / Phlebotomus Fever / Disseminated Intravascular Coagulation / Tick Bites Type of study: Diagnostic_studies Limits: Aged / Female / Humans Language: En Journal: J Dermatol Year: 2019 Document type: Article Affiliation country: Japan