Lights and shadows of electrophile signaling: focus on the Nrf2-Keap1 pathway.

Basagni, Filippo; Lanni, Cristina; Minarini, Anna; Rosini, Michela

Basagni, Filippo; Lanni, Cristina; Minarini, Anna; Rosini, Michela.

Affiliation

Basagni F; Department of Pharmacy & Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Lanni C; Department of Drug Sciences (Pharmacology Section), V.le Taramelli 14, 27100 Pavia, Italy.
Minarini A; Department of Pharmacy & Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
Rosini M; Department of Pharmacy & Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.

Future Med Chem ; 11(7): 707-721, 2019 04.

Article in En | MEDLINE | ID: mdl-30942112

Subject(s)

Antioxidants/chemistry; Kelch-Like ECH-Associated Protein 1/metabolism; NF-E2-Related Factor 2/metabolism; Animals; Antioxidants/pharmacology; Cysteine/metabolism; Dimethyl Fumarate/chemistry; Dimethyl Fumarate/pharmacology; Drug Design; Humans; Molecular Structure; Oleanolic Acid/analogs & derivatives; Oleanolic Acid/chemistry; Oleanolic Acid/pharmacology; Oxidation-Reduction; Oxidative Stress; Signal Transduction; Structure-Activity Relationship

Key words

Nrf2Keap1 pathway; cysteine trapping; electrophilic compounds; redox signaling; covalent adduct

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: NF-E2-Related Factor 2 / Kelch-Like ECH-Associated Protein 1 / Antioxidants Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Future Med Chem Year: 2019 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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