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Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection.
Macchione, Micaela A; Guerrero-Beltrán, Carlos; Rosso, Anabella P; Euti, Esteban M; Martinelli, Marisa; Strumia, Miriam C; Muñoz-Fernández, Maria Ángeles.
Affiliation
  • Macchione MA; Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica. Av. Haya de la Torre esq. Av. Medina Allende, Córdoba, X5000HUA, Argentina.
  • Guerrero-Beltrán C; CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA). Av. Velez Sárfield 1611, Córdoba, X5000HUA, Argentina.
  • Rosso AP; Sección Inmunología, Laboratorio Inmuno Biología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, 28007, Spain.
  • Euti EM; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, 28007, Spain.
  • Martinelli M; Spanish HIV HGM Biobank, Madrid, 28007, Spain.
  • Strumia MC; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, 28029, Spain.
  • Muñoz-Fernández MÁ; Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica. Av. Haya de la Torre esq. Av. Medina Allende, Córdoba, X5000HUA, Argentina.
Sci Rep ; 9(1): 5732, 2019 04 05.
Article in En | MEDLINE | ID: mdl-30952921
ABSTRACT
Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Polymers / Virus Replication / Caprolactam / Cell Survival / HIV-1 / Nanogels Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Argentina
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Polymers / Virus Replication / Caprolactam / Cell Survival / HIV-1 / Nanogels Language: En Journal: Sci Rep Year: 2019 Document type: Article Affiliation country: Argentina