Uncoupling nNOS-PSD-95 in the ACC can inhibit contextual fear generalization.
Biochem Biophys Res Commun
; 513(1): 248-254, 2019 05 21.
Article
in En
| MEDLINE
| ID: mdl-30954227
ABSTRACT
A typical feature of the contextual fear memory is increased fear generalization with time. Though much attention has been given to the neural structures that underlie the long-term consolidation of a contextual fear memory, the molecular mechanisms regulating fear generalization remain unclear. We observed that retrieval of contextual fear in a novel context at a remote time point increased coupling of neuronal nitric oxide synthase (nNOS) with postsynaptic density-95 (PSD-95) and c-Fos expression in the anterior cingulate cortex (ACC). Disrupting nNOS-PSD-95 coupling in the ACC decreased the expression of Histone deacetylase 2 (HDAC2), and inhibited contextual fear generalization at a remote time point. Together, our findings reveal nNOS-PSD-95 interaction in the ACC could be a promising target to prevent or reverse contextual fear generalization.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nitric Oxide Synthase Type I
/
Guanylate Kinases
/
Fear
/
Gyrus Cinguli
/
Membrane Proteins
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2019
Document type:
Article
Affiliation country:
China