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Elucidation and partial NMR assignment of monosulfated maitotoxins from the Caribbean.
Mazzola, Eugene P; Deeds, Jonathan R; Stutts, Whitney L; Ridge, Clark D; Dickey, Robert W; White, Kevin D; Williamson, R Thomas; Martin, Gary E.
Affiliation
  • Mazzola EP; University of Maryland-FDA Joint Institute, College Park, MD, 20742, USA.
  • Deeds JR; Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD, 20740, USA.
  • Stutts WL; Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD, 20740, USA.
  • Ridge CD; Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD, 20740, USA. Electronic address: clark.ridge@fda.hhs.gov.
  • Dickey RW; Food and Drug Administration Gulf Coast Seafood Laboratory, Office of Food Safety, Dauphin Island, AL, 36528, USA.
  • White KD; Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD, 20740, USA.
  • Williamson RT; Merck Research Laboratories, Process and Analytical Chemistry, NMR Structure Elucidation Group, Rahway, NJ, 07065, USA.
  • Martin GE; Merck Research Laboratories, Process and Analytical Chemistry, NMR Structure Elucidation Group, Rahway, NJ, 07065, USA.
Toxicon ; 164: 44-50, 2019 Jun.
Article in En | MEDLINE | ID: mdl-30954452
Compounds similar to maitotoxin (MTX) have been isolated from several laboratory strains of the dinoflagellate Gambierdiscus spp. from the Caribbean. Mass spectral results suggest that these compounds differ from MTX by the loss of one sulfate group and, in some cases, the loss of one methyl group with the addition of one degree of unsaturation. NMR experiments, using approximately 50 nmol of one of these compounds, have demonstrated that the 9-sulfo group of MTX is still present, suggesting that these compounds are 40-desulfo congeners of MTX.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dinoflagellida / Oxocins / Marine Toxins Language: En Journal: Toxicon Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dinoflagellida / Oxocins / Marine Toxins Language: En Journal: Toxicon Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom