Omega-3 fatty acids differentially influences embryotoxicity in subtypes of preeclampsia.
Clin Exp Hypertens
; 42(3): 205-212, 2020.
Article
in En
| MEDLINE
| ID: mdl-30964712
ABSTRACT
Background:
Early (EOP) and late onset (LOP) preeclampsia are two subtypes of preeclampsia. This study examines the effect of maternal omega-3 fatty acids and vitamin E supplementation in a rat model of preeclampsia.Method:
Pregnant Wistar rats were assigned to control; EOP; LOP; EOP+omega-3 fatty acid supplementation+vitamin E and LOP+omega-3 fatty acid supplementation+vitamin E. L-Nitroarginine methylester was used to induce preeclampsia. Blood Pressure (BP) was recorded during pregnancy and dams were dissected at d14 and d20 of gestation.Results:
Animals from EOP and LOP groups demonstrated higher systolic and diastolic BP, lower weight gain, lower conceptuses size, lower conceptuses weight and fetal weight as compared to control. EOP and LOP groups showed higher percentage of fetal resorptions and embryotoxicity (deformities and hematomas).Conclusion:
Supplementation reduced the diastolic BP, percentage of resorptions and embryotoxicity only in the LOP group, suggesting a need for differential supplementation regime for the two subtypes of preeclampsia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pre-Eclampsia
/
Vitamin E
/
Blood Pressure
/
Fatty Acids, Omega-3
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Clin Exp Hypertens
Year:
2020
Document type:
Article
Affiliation country:
India