Synthesis, in vivo anticonvulsant testing, and molecular modeling studies of new nafimidone derivatives.

Acar, Mustafa F; Sari, Suat; Dalkara, Sevim

Acar, Mustafa F; Sari, Suat; Dalkara, Sevim.

Affiliation

Acar MF; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, Turkey.
Sari S; Server Gazi Pharmacy, Merkez Efendi, Denizli, Turkey.
Dalkara S; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Hacettepe University, Ankara, Turkey.

Drug Dev Res ; 80(5): 606-616, 2019 08.

Article in En | MEDLINE | ID: mdl-30973979

Subject(s)

Anticonvulsants/chemical synthesis; Electroshock/adverse effects; Imidazoles/chemical synthesis; Receptors, GABA-A/metabolism; Seizures/drug therapy; Administration, Oral; Animals; Anticonvulsants/chemistry; Anticonvulsants/pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles/chemistry; Imidazoles/pharmacology; Injections, Intraperitoneal; Male; Mice; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Naphazoline/analogs & derivatives; Naphazoline/chemistry; Rats; Receptors, GABA-A/chemistry; Seizures/etiology; Seizures/metabolism; Structure-Activity Relationship

Key words

(arylalkyl)azole; esterification; molecular docking

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Receptors, GABA-A / Electroshock / Imidazoles / Anticonvulsants Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Drug Dev Res Year: 2019 Document type: Article Affiliation country: Turkey Country of publication: United States

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