FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.

McClements, Lana; Annett, Stephanie; Yakkundi, Anita; O'Rourke, Martin; Valentine, Andrea; Moustafa, Nermeen; Alqudah, Abdelrahim; Simões, Bruno M; Furlong, Fiona; Short, Amy; McIntosh, Stuart A; McCarthy, Helen O; Clarke, Robert B; Robson, Tracy

McClements, Lana; Annett, Stephanie; Yakkundi, Anita; O'Rourke, Martin; Valentine, Andrea; Moustafa, Nermeen; Alqudah, Abdelrahim; Simões, Bruno M; Furlong, Fiona; Short, Amy; McIntosh, Stuart A; McCarthy, Helen O; Clarke, Robert B; Robson, Tracy.

Affiliation

McClements L; Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Annett S; School of Pharmacy, Queen's University Belfast, Belfast, UK.
Yakkundi A; The School of Life Sciences, University of Technology Sydney, Sydney, Australia.
O'Rourke M; School of Pharmacy, Queen's University Belfast, Belfast, UK.
Valentine A; Department of Molecular and Cellular Therapeutics, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland.
Moustafa N; School of Pharmacy, Queen's University Belfast, Belfast, UK.
Alqudah A; School of Pharmacy, Queen's University Belfast, Belfast, UK.
Simões BM; Charles River Labs, 8-9 Spire Green Centre, Essex, Harlow, CM19 5TR, UK.
Furlong F; School of Pharmacy, Queen's University Belfast, Belfast, UK.
Short A; Charles River Labs, 8-9 Spire Green Centre, Essex, Harlow, CM19 5TR, UK.
McIntosh SA; School of Pharmacy, Queen's University Belfast, Belfast, UK.
McCarthy HO; Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Clarke RB; School of Pharmacy, Hashemite University, Amman, Jordan.
Robson T; Manchester Breast Centre, Division of Cancer Sciences, University of Manchester, Oglesby Cancer Research Building, Manchester, UK.

BMC Cancer ; 19(1): 351, 2019 Apr 11.

Article in En | MEDLINE | ID: mdl-30975104

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Breast Neoplasms/drug therapy; Immunophilins/pharmacology; Neoplastic Stem Cells/drug effects; Peptides/pharmacology; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Hormonal/pharmacology; Antineoplastic Agents, Hormonal/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Breast/pathology; Breast Neoplasms/pathology; Calcium-Binding Proteins; Cell Line, Tumor; Down-Regulation/drug effects; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Immunophilins/therapeutic use; Intercellular Signaling Peptides and Proteins/metabolism; Mice; Mice, SCID; Neoplasm Recurrence, Local/prevention & control; Neoplastic Stem Cells/pathology; Peptides/therapeutic use; Receptor, Notch4/metabolism; Signal Transduction/drug effects; Tacrolimus Binding Proteins; Tamoxifen/pharmacology; Tamoxifen/therapeutic use; Treatment Outcome; Xenograft Model Antitumor Assays

Key words

AD-01; ALM201; Breast cancer stem cells; DLL4; Endocrine therapy; Estrogen receptor; FKBPL; Letrozole; Metastasis; Notch4; Tamoxifen; Triple negative breast cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Neoplastic Stem Cells / Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Immunophilins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2019 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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