Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana.
PLoS Negl Trop Dis
; 13(4): e0007309, 2019 04.
Article
in En
| MEDLINE
| ID: mdl-30986220
ABSTRACT
INTRODUCTION:
The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data.METHODS:
Paracoccidioides strains from INI/Fiocruz patients (1998-2016) were recovered. Socio-demographic, epidemiological, clinical, serological, therapeutic and prognostic data of the patients were collected to evaluate possible associations of these variables with the fungal species identified through partial sequencing of the ADP-ribosylation factor (arf) and the 43-kDa-glycoprotein (gp43) genes.RESULTS:
Fifty-four fungal strains were recovered from 47 patients, most (72.3%) infected in Rio de Janeiro state, Brazil. Forty-one cases were caused by Paracoccidioides brasiliensis and six by Paracoccidioides americana (former PS2). P. brasiliensis was responsible for severe lymph abdominal forms, whereas patients infected with P. americana presented a high rate of adrenal involvement. However, no statistically significant associations were found for all variables studied. P. americana presented 100% reactivity to immunodiffusion, even when tested against antigens from other species, while negative results were observed in 9 (20%) cases caused by P. brasiliensis, despite being tested against a homologous antigen.CONCLUSIONS:
P. brasiliensis and P. americana are sympatric and share similar clinical features and habitat, where they may compete for similar hosts.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paracoccidioides
/
Paracoccidioidomycosis
/
Sympatry
/
Genetic Background
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
PLoS Negl Trop Dis
Journal subject:
MEDICINA TROPICAL
Year:
2019
Document type:
Article
Affiliation country:
Brazil