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The Antiviral Apparatus: STING and Oncolytic Virus Restriction.
Lee, Joel; Ghonime, Mohammed G; Wang, Ruoning; Cassady, Kevin A.
Affiliation
  • Lee J; The Ohio State University College of Medicine, Biomedical Sciences Graduate Program, Columbus, OH 43210, USA.
  • Ghonime MG; The Research Institute at Nationwide Children's Hospital Center for Childhood Cancer and Blood Disorders, The Ohio State University, Columbus, OH, USA.
  • Wang R; The Research Institute at Nationwide Children's Hospital Center for Childhood Cancer and Blood Disorders, The Ohio State University, Columbus, OH, USA.
  • Cassady KA; The Research Institute at Nationwide Children's Hospital Center for Childhood Cancer and Blood Disorders, The Ohio State University, Columbus, OH, USA.
Mol Ther Oncolytics ; 13: 7-13, 2019 Jun 28.
Article in En | MEDLINE | ID: mdl-30989105
ABSTRACT
A network of pattern recognition receptors (PRRs) is responsible for the detection of invading viruses and acts as the trigger for the host antiviral response. Central to this apparatus is stimulator of interferon genes (STING), which functions as a node and integrator of detection signals. Owing to its role in both intrinsic and adaptive immunity, STING has become a focus for researchers in the field of oncolytic virotherapy. In this review, we consider the function of the cGAS-STING axis and its regulation, both by cellular mechanisms and as a result of viral interference.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Ther Oncolytics Year: 2019 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Mol Ther Oncolytics Year: 2019 Document type: Article Affiliation country: United States