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High Stability of a Donor-Acceptor Type Oxazepine-Containing Fluorophore and Its Applications in Cellular Imaging and Two-Photon Deep Tissue Imaging.
Moon, Heejo; Jung, Yuna; Kim, Youngseo; Kim, Byeong Wook; Choi, Jin Gyu; Kim, Na Hee; Oh, Myung Sook; Park, Sungnam; Kim, B Moon; Kim, Dokyoung.
Affiliation
  • Moon H; Department of Chemistry, College of Natural Sciences , Seoul National University , Seoul 08826 , Republic of Korea.
  • Kim Y; Department of Chemistry , Korea University , Seoul 02841 , Republic of Korea.
  • Kim BW; Department of Chemistry, College of Natural Sciences , Seoul National University , Seoul 08826 , Republic of Korea.
  • Park S; Department of Chemistry , Korea University , Seoul 02841 , Republic of Korea.
  • Kim BM; Department of Chemistry, College of Natural Sciences , Seoul National University , Seoul 08826 , Republic of Korea.
Org Lett ; 21(11): 3891-3894, 2019 06 07.
Article in En | MEDLINE | ID: mdl-30990046
ABSTRACT
A new donor (D)-acceptor (A) type naphthalene-based oxazepine-containing fluorophore, OXN-1, is reported, which shows unusually high stability in various environments. Its photophysical properties and structural stabilities under harsh conditions are thoroughly examined. The high stability of OXN-1 is explained by quantum chemical calculations. Its exceptional bioimaging capabilities for cells with low cytotoxicity are verified. In addition, its deep tissue imaging ability with two-photon microscopy (TPM) is evaluated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / Photons / Optical Imaging / Fluorescent Dyes / Kidney / Liver / Lung Limits: Animals / Humans Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / Photons / Optical Imaging / Fluorescent Dyes / Kidney / Liver / Lung Limits: Animals / Humans Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2019 Document type: Article