Identification of novel imidazole flavonoids as potent and selective inhibitors of protein tyrosine phosphatase.

Zhang, Ling; Ge, Yu; Wang, Qing Ming; Zhou, Cheng-He

Zhang, Ling; Ge, Yu; Wang, Qing Ming; Zhou, Cheng-He.

Affiliation

Zhang L; School of Pharmacy, Yancheng Teachers' University, Yancheng, Jiangsu 224051, People's Republic of China. Electronic address: zhangl@yctu.edu.cn.
Ge Y; School of Pharmacy, Yancheng Teachers' University, Yancheng, Jiangsu 224051, People's Republic of China.
Wang QM; School of Pharmacy, Yancheng Teachers' University, Yancheng, Jiangsu 224051, People's Republic of China. Electronic address: wangqm@yctu.edu.cn.
Zhou CH; Laboratory of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People's Republic of China.

Bioorg Chem ; 88: 102900, 2019 07.

Article in En | MEDLINE | ID: mdl-30991192

Subject(s)

Enzyme Inhibitors/pharmacology; Flavonoids/pharmacology; Imidazoles/pharmacology; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 2/antagonists & inhibitors; Catalytic Domain; Cell Survival/drug effects; Enzyme Assays; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/metabolism; Enzyme Inhibitors/toxicity; Flavonoids/chemical synthesis; Flavonoids/metabolism; Flavonoids/toxicity; HEK293 Cells; Humans; Imidazoles/chemical synthesis; Imidazoles/metabolism; Imidazoles/toxicity; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 2/chemistry; Protein Tyrosine Phosphatase, Non-Receptor Type 2/metabolism

Key words

Cell viability; Flavonoid; Imidazole; Protein tyrosine phosphatase; Selectivity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Enzyme Inhibitors / Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Protein Tyrosine Phosphatase, Non-Receptor Type 2 / Imidazoles Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Document type: Article Country of publication: United States

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