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Design, synthesis and biological activity of deuterium-based FFA1 agonists with improved pharmacokinetic profiles.
Liu, Bing; Deng, Liming; Chen, Haidong; Liao, Ruoxian; Li, Yuyi; Zeng, Xiaohua; Deng, Fengjian; Zhang, Luyong; Li, Zheng.
Affiliation
  • Liu B; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Guangzhou Key Laboratory of Construction and Appli
  • Deng L; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • Chen H; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • Liao R; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • Li Y; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • Zeng X; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • Deng F; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • Zhang L; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Guangzhou Key Laboratory of Construction and Appli
  • Li Z; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address: li.zheng.sky@163.com.
Bioorg Med Chem Lett ; 29(12): 1471-1475, 2019 06 15.
Article in En | MEDLINE | ID: mdl-30992164
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, G-Protein-Coupled / Deuterium Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, G-Protein-Coupled / Deuterium Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Document type: Article Country of publication: United kingdom