C-phycocyanin from <i>Limnothrix</i> Species KNUA002 Alleviates Cisplatin-Induced Ototoxicity by Blocking the Mitochondrial Apoptotic Pathway in Auditory Cells.

Kim, Ye-Ri; Do, Jeong-Mi; Kim, Kyung Hee; Stoica, Alexandra R; Jo, Seung-Woo; Kim, Un-Kyung; Yoon, Ho-Sung

C-phycocyanin from Limnothrix Species KNUA002 Alleviates Cisplatin-Induced Ototoxicity by Blocking the Mitochondrial Apoptotic Pathway in Auditory Cells.

Kim, Ye-Ri; Do, Jeong-Mi; Kim, Kyung Hee; Stoica, Alexandra R; Jo, Seung-Woo; Kim, Un-Kyung; Yoon, Ho-Sung.

Affiliation

Kim YR; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea. yell_90@knu.ac.kr.
Do JM; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea. yell_90@knu.ac.kr.
Kim KH; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea. leciel631@naver.com.
Stoica AR; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea. leciel631@naver.com.
Jo SW; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea. kkh5566@knu.ac.kr.
Kim UK; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea. kkh5566@knu.ac.kr.
Yoon HS; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea. alexa_stoica93@yahoo.ro.

Mar Drugs ; 17(4)2019 Apr 19.

Article in En | MEDLINE | ID: mdl-31010222

Subject(s)

Antineoplastic Agents/toxicity; Cisplatin/toxicity; Cyanobacteria/chemistry; Hair Cells, Auditory/drug effects; Hearing Loss/chemically induced; Hearing Loss/drug therapy; Phycocyanin/pharmacology; Animals; Apoptosis/drug effects; Caspase 3/metabolism; Cell Cycle Checkpoints/drug effects; Cell Line; Cell Survival/drug effects; Cyanobacteria/metabolism; Hair Cells, Auditory/metabolism; Hearing Loss/metabolism; Mice; Mitochondria/drug effects; Mitochondria/metabolism; Protective Agents/pharmacology; Proto-Oncogene Proteins c-bcl-2/metabolism; Reactive Oxygen Species/metabolism; bcl-2-Associated X Protein/metabolism

Key words

C-phycocyanin; HEI-OC1; Limnothrix; cisplatin; ototoxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phycocyanin / Cisplatin / Cyanobacteria / Hair Cells, Auditory / Hearing Loss / Antineoplastic Agents Limits: Animals Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2019 Document type: Article

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