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Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study.
Nadareishvili, Zurab; Kelley, Devon; Luby, Marie; Simpkins, Alexis N; Leigh, Richard; Lynch, John K; Hsia, Amie W; Benson, Richard T; Johnson, Kory R; Hallenbeck, John M; Latour, Lawrence L.
Affiliation
  • Nadareishvili Z; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Kelley D; Department of Neurology George Washington University Washington District of Columbia.
  • Luby M; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Simpkins AN; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Leigh R; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Lynch JK; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Hsia AW; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Benson RT; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Johnson KR; Medstar Washington Hospital Center Stroke Center Washington District of Columbia.
  • Hallenbeck JM; Section on Stroke Diagnostics and Therapeutics NINDS NIH Bethesda Maryland.
  • Latour LL; Medstar Washington Hospital Center Stroke Center Washington District of Columbia.
Ann Clin Transl Neurol ; 6(4): 817-820, 2019 Apr.
Article in En | MEDLINE | ID: mdl-31020007
We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion-diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion-diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score -2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Ischemia / Cerebrovascular Circulation / Stroke Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Ann Clin Transl Neurol Year: 2019 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Brain Ischemia / Cerebrovascular Circulation / Stroke Type of study: Diagnostic_studies / Prognostic_studies Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Ann Clin Transl Neurol Year: 2019 Document type: Article Country of publication: United States