Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma.
Future Oncol
; 15(16): 1911-1920, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-31020849
ABSTRACT
Aim:
To assess the clinical features/imaging characteristics of pneumonitis reported during nationwide nivolumab postmarketing surveillance in Japan. Patients &methods:
Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case.Results:
Among 144 cases analyzed, 91 (63.2%) had radiological patterns considered typical for drug-induced pneumonitis and 53 (36.8%) patients had previously unobserved patterns with one or more atypical features, including 23 cases (16.0%) with ground glass opacity confined to the area around the tumor (peritumoral infiltration). A higher proportion of patients with (vs without) peritumoral infiltration had an antitumor response to nivolumab.Conclusion:
Images of nivolumab-induced pneumonitis showed previously unobserved radiological patterns.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia
/
Carcinoma, Non-Small-Cell Lung
/
Antineoplastic Agents, Immunological
/
Nivolumab
/
Lung Neoplasms
/
Melanoma
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Future Oncol
Year:
2019
Document type:
Article
Affiliation country:
Japan