Penicillin-induced Cutaneous Necrotizing Eosinophilic Vasculitis with Cryofibrinogenemia.
Acta Dermatovenerol Croat
; 27(1): 28-32, 2019 Mar.
Article
in En
| MEDLINE
| ID: mdl-31032788
ABSTRACT
Cutaneous necrotizing eosinophilic vasculitis (CNEV) is a rare type of vasculitis. Eosinophilic vasculitis is a necrotizing vasculitis with eosinophilic vascular infiltration, in which eosinophils mediate vascular damage in the disease process. We present a case of an 18-year-old girl who developed palpable purpura and hemorrhagic bullae over the lower extremities associated with itching, 7 days after the commencement of penicillin therapy. Plasma cryofibrinogen was positive. Histopathology showed an infiltration of eosinophils within and around the vessel walls and a complete absence of nuclear dust and neutrophils. Oral prednisone at 1 mg/kg induced remission in 2 weeks; the prednisone dose was tapered and discontinued after 2.5 months. There was no evidence of recurrence after 37 months of follow-up. Our patient represents a rare case of drug/penicillin-induced CNEV associated with cryofibrinogenemia, without systemic organ involvement.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Penicillins
/
Vasculitis
/
Cryoglobulinemia
/
Eosinophilia
/
Anti-Bacterial Agents
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
Acta Dermatovenerol Croat
Journal subject:
DERMATOLOGIA
Year:
2019
Document type:
Article