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In vivo resorption of injectable apatitic calcium phosphate cements: Critical role of the intergranular microstructure.
Le Ferrec, Myriam; Mellier, Charlotte; Lefèvre, Francois-Xavier; Boukhechba, Florian; Janvier, Pascal; Montavon, Gilles; Bouler, Jean-Michel; Gauthier, Olivier; Bujoli, Bruno.
Affiliation
  • Le Ferrec M; Graftys SA, Pôle d'activités d'Aix en Provence, Aix en Provence, France.
  • Mellier C; SUBATECH, UMR CNRS 6457, IMT Atlantique Bretagne-Pays de la Loire, Nantes, France.
  • Lefèvre FX; Graftys SA, Pôle d'activités d'Aix en Provence, Aix en Provence, France.
  • Boukhechba F; CEISAM, Université de Nantes, CNRS, UMR 6230, Nantes, France.
  • Janvier P; Graftys SA, Pôle d'activités d'Aix en Provence, Aix en Provence, France.
  • Montavon G; CEISAM, Université de Nantes, CNRS, UMR 6230, Nantes, France.
  • Bouler JM; SUBATECH, UMR CNRS 6457, IMT Atlantique Bretagne-Pays de la Loire, Nantes, France.
  • Gauthier O; CEISAM, Université de Nantes, CNRS, UMR 6230, Nantes, France.
  • Bujoli B; RMeS, UMR 1229, Université de Nantes, INSERM, Nantes, France.
J Biomed Mater Res B Appl Biomater ; 108(2): 367-376, 2020 02.
Article in En | MEDLINE | ID: mdl-31033211
The in vivo resorption rate of two injectable apatitic calcium phosphate cements used in clinics (Graftys® HBS and NORIAN®) was compared, using a good laboratory practice (GLP) study based on an animal model of critical-sized bone defect. To rationalize the markedly different biological properties observed for both cements, key physical features were investigated, including permeability and water-accessible porosity, total porosity measured by mercury intrusion and gravimetry, and microstructure. Due to a different concept for creating porosity between the two cements investigated in this study, a markedly different microstructural arrangement of apatite crystals was observed in the intergranular space, which was found to significantly influence both the mechanical strength and in vivo degradation of the two calcium phosphate cements.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apatites / Bone Cements / Tissue Scaffolds Limits: Animals Language: En Journal: J Biomed Mater Res B Appl Biomater Journal subject: ENGENHARIA BIOMEDICA Year: 2020 Document type: Article Affiliation country: France Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apatites / Bone Cements / Tissue Scaffolds Limits: Animals Language: En Journal: J Biomed Mater Res B Appl Biomater Journal subject: ENGENHARIA BIOMEDICA Year: 2020 Document type: Article Affiliation country: France Country of publication: United States