Efficient discovery of novel antimicrobials through integration of synthesis and testing in crude ribosome extract.

Sang, Zitai; Lu, Yongping; Zhou, Yuanzheng; Ju, Yuan; An, Qi; Shen, Silan; Shi, Jianyou; He, Jun; Yang, Tao; Luo, Youfu

Sang, Zitai; Lu, Yongping; Zhou, Yuanzheng; Ju, Yuan; An, Qi; Shen, Silan; Shi, Jianyou; He, Jun; Yang, Tao; Luo, Youfu.

Affiliation

Sang Z; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China. luo_youfu@scu.edu.cn.

Chem Commun (Camb) ; 55(42): 5886-5889, 2019 May 21.

Article in En | MEDLINE | ID: mdl-31041938

Subject(s)

Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Bacteria/drug effects; Drug Discovery; Ribosomes/drug effects; Chromatography, High Pressure Liquid; Click Chemistry; Cycloaddition Reaction; Drug Resistance, Bacterial; High-Throughput Screening Assays; Inhibitory Concentration 50; Mass Spectrometry; Microbial Sensitivity Tests; Proof of Concept Study; Protein Biosynthesis/drug effects; Transcription, Genetic/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ribosomes / Bacteria / Drug Discovery / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: China Country of publication: United kingdom

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