Increased frequency of the restless legs syndrome in adults with cystic fibrosis.
Respir Med
; 151: 8-10, 2019 05.
Article
in En
| MEDLINE
| ID: mdl-31047121
ABSTRACT
BACKGROUND:
Patients with cystic fibrosis (CF) may suffer from iron deficiency which is a known risk factor for the restless legs syndrome (RLS), however, its prevalence has not yet been investigated in these subjects. PATIENTS ANDMETHODS:
Adult out-patients with CF (nâ¯=â¯39) and healthy volunteers (nâ¯=â¯32) were recruited for this study. A diagnosis of RLS was made based on the diagnostic criteria established by the International Restless Legs Syndrome Study Group (IRLSSG). The IRLSSG rating scale was used to assess the severity of the disease. Furthermore, in the CF group, parameters of iron metabolism were measured in peripheral venous blood samples.RESULTS:
The RLS occurred more frequently in the CF patients than the controls (nâ¯=â¯13/33,3% vs. nâ¯=â¯2/6,3%; pâ¯<â¯0,05). In the CF patients suffering from RLS, the mean score of the IRLSSG rating scale was 17,2⯱â¯9,4 indicating moderate disease severity. Iron deficiency was present in the majority of the CF patients investigated (nâ¯=â¯33/84,6%), however, serum iron, ferritin and transferrin levels as well as transferrin saturation were similar in those with vs. without RLS.CONCLUSIONS:
The frequency of the RLS is increased in adult patients with CF. On an average, its severity is moderate and it is not related to iron deficiency as evaluated by serum parameters of iron metabolism.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Restless Legs Syndrome
/
Cystic Fibrosis
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Respir Med
Year:
2019
Document type:
Article
Affiliation country:
Germany