Biomarkers of mineral metabolism and progression of aortic valve and mitral annular calcification: The Multi-Ethnic Study of Atherosclerosis.
Atherosclerosis
; 285: 79-86, 2019 06.
Article
in En
| MEDLINE
| ID: mdl-31048102
ABSTRACT
BACKGROUND AND AIMS:
Previous research has implicated dysregulation of phosphate metabolism and calcium-phosphate solubilization in cardiovascular calcification, but epidemiologic studies evaluating longitudinal associations with valvular or annular calcification by computed tomography (CT), a highly sensitive imaging modality, are lacking. Our primary aim was to investigate the associations of mineral biomarkers with incidence and progression of aortic valve calcification (AVC) and mitral annular calcification (MAC).METHODS:
We evaluated the associations of serum FGF-23 (nâ¯=â¯6547 participants), phosphate (nâ¯=â¯6547), and fetuin-A (nâ¯=â¯2550) measured at baseline in the community-based Multi-Ethnic Study of Atherosclerosis with AVC and MAC on CT performed at baseline and at a median of 2.4 (1.6, 3.1) years later. We used linear mixed-effects models to account simultaneously for prevalence, incidence and progression of AVC and MAC.RESULTS:
After adjustment for demographic and clinical characteristics, a significant association was documented for FGF-23 with accelerated annual progression of MAC (2.83 Agatston units (AU), 95% CIâ¯=â¯0.49, 5.17 AU, per standard deviation (18.46â¯pg/mL) of FGF-23), but this was not seen for phosphate or fetuin-A. None of these biomarkers was associated with accelerated annual progression of AVC.CONCLUSIONS:
This study provides evidence relating serum FGF-23 to accelerated annual MAC progression. Whether this mineral regulator is a risk marker or is involved in pathogenesis merits further investigation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aortic Valve
/
Aortic Valve Stenosis
/
Calcinosis
/
Atherosclerosis
/
Fibroblast Growth Factors
/
Heart Valve Diseases
/
Mitral Valve
Type of study:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged80
Country/Region as subject:
America do norte
Language:
En
Journal:
Atherosclerosis
Year:
2019
Document type:
Article
Affiliation country:
United States