Your browser doesn't support javascript.
loading
A Transmissible RNA Pathway in Honey Bees.
Maori, Eyal; Garbian, Yael; Kunik, Vered; Mozes-Koch, Rita; Malka, Osnat; Kalev, Haim; Sabath, Niv; Sela, Ilan; Shafir, Sharoni.
Affiliation
  • Maori E; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK. Electronic address: eyalmm@gmail.com.
  • Garbian Y; The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 7610001, Israel.
  • Kunik V; Bioinformatics Consulting, 12 Hailanot Street, Gat-Rimon 4992000, Israel.
  • Mozes-Koch R; The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 7610001, Israel.
  • Malka O; The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 7610001, Israel.
  • Kalev H; The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 7610001, Israel.
  • Sabath N; Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
  • Sela I; The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 7610001, Israel.
  • Shafir S; The Hebrew University of Jerusalem, The Robert H. Smith Faculty of Agriculture, Food and Environment, Rehovot 7610001, Israel.
Cell Rep ; 27(7): 1949-1959.e6, 2019 05 14.
Article in En | MEDLINE | ID: mdl-31056439
Systemic RNAi, initiated by double-stranded RNA (dsRNA) ingestion, has been reported in diverse invertebrates, including honey bees, demonstrating environmental RNA uptake that undermines homologous gene expression. However, the question why any organism would take up RNA from the environment has remained largely unanswered. Here, we report on horizontal RNA flow among honey bees mediated by secretion and ingestion of worker and royal jelly diets. We demonstrate that transmission of jelly-secreted dsRNA to larvae is biologically active and triggers gene knockdown that lasts into adulthood. Worker and royal jellies harbor differential naturally occurring RNA populations. Jelly RNAs corresponded to honey bee protein-coding genes, transposable elements, and non-coding RNA, as well as bacteria, fungi, and viruses. These results reveal an inherent property of honey bees to share RNA among individuals and generations. Our findings suggest a transmissible RNA pathway, playing a role in social immunity and signaling between members of the hive.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bees / RNA, Double-Stranded / Signal Transduction / RNA Interference Limits: Animals Language: En Journal: Cell Rep Year: 2019 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bees / RNA, Double-Stranded / Signal Transduction / RNA Interference Limits: Animals Language: En Journal: Cell Rep Year: 2019 Document type: Article Country of publication: United States