Laryngeal distribution of adult-onset recurrent respiratory papillomatosis: A longitudinal study.
Laryngoscope
; 129(9): 1993-1997, 2019 09.
Article
in En
| MEDLINE
| ID: mdl-31059600
ABSTRACT
OBJECTIVES/HYPOTHESIS:
To describe recurrence patterns in patients with recurrent respiratory papillomatosis (RRP) following surgical intervention. STUDYDESIGN:
Single-center, retrospective, longitudinal case series.METHODS:
Initial and follow-up laryngoscopic examinations of seven previously untreated adult-onset RRP patients were reviewed. Patients were followed longitudinally for periods ranging from 3 months to 7 years. Lesion locations were recorded using a twenty-one region laryngeal schematic, and maps were generated to illustrate the distribution of disease before and after cold-knife or potassium-titanyl-phosphate laser intervention. Univariate and multivariate analyses were employed to examine variables affecting recurrence patterns.RESULTS:
Across all patients, a statistically significant correlation between initial distribution and primary recurrence was observed. Seventy-five percent of new lesions were adjacent to regions with preexisting disease; 83% of new glottic lesions were adjacent to preexisting glottic lesions, and 66% of supraglottic lesions were adjacent to preexisting supraglottic regions. No statistically significant differences in recurrence rate were observed across sites.CONCLUSIONS:
In previously untreated patients with adult-onset recurrent respiratory papillomatosis, lesions tended to recur either in the same regions or regions adjacent to those affected at the time of initial surgery. LEVEL OF EVIDENCE 4 Laryngoscope, 1291993-1997, 2019.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Tract Infections
/
Papillomavirus Infections
/
Glottis
Type of study:
Evaluation_studies
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Laryngoscope
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2019
Document type:
Article
Affiliation country:
United States