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Altered DNA methylation of the AluY subfamily in schizophrenia and bipolar disorder.
Li, Shufen; Zong, Lu; Hou, Yu; Zhang, Wenwei; Zhou, Lin; Yang, Qiong; Wang, Lijuan; Jiang, Wei; Li, Qiyang; Huang, Xingbing; Ning, Yuping; Wen, Zhexing; Zhao, Cunyou.
Affiliation
  • Li S; Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China.
  • Zong L; Center for Reproductive Medicine, The First Affiliated Hospital of University of Science & Technology of China, Hefei, Anhui, China.
  • Hou Y; Department of Pediatric Neurology, Affiliated BaYi Children's Hospital, PLA Army General Hospital, Beijing, China.
  • Zhang W; Department of Psychiatry, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong, China.
  • Zhou L; Key Laboratory of Genetics & Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha, China.
  • Yang Q; Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong, China.
  • Wang L; Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China.
  • Jiang W; Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China.
  • Li Q; Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China.
  • Huang X; Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong, China.
  • Ning Y; Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong, China.
  • Wen Z; Departments of Psychiatry and Behavior Sciences, Cell Biology, and Neurology, Emory University, Atlanta, GA, USA.
  • Zhao C; Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China.
Epigenomics ; 11(6): 581-586, 2019 05.
Article in En | MEDLINE | ID: mdl-31066577
Aim: To study DNA methylation patterns of AluY subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). Patients & methods: A bisulfite conversion-specific one-label extension method was employed to detect the AluY subfamily methylation levels of peripheral blood DNA from 92 SCZ patients, 99 BPD patients and 92 controls. Results: Hypermethylation of the AluY A1 and A2 CpG sites in BPD patients and hypomethylation of A3 CpG site in both of BPD and SCZ patients, and opposite age-dependent methylation alterations between SCZ and controls. Conclusion: The differentially altered DNA methylation patterns of the AluY families between BPD and SCZ suggest the role of DNA methylation in the pathogenesis of these major psychiatric disorders.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Bipolar Disorder / DNA Methylation / Alu Elements Limits: Humans Language: En Journal: Epigenomics Year: 2019 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Bipolar Disorder / DNA Methylation / Alu Elements Limits: Humans Language: En Journal: Epigenomics Year: 2019 Document type: Article Affiliation country: China Country of publication: United kingdom