Early detonation by sprouted mossy fibers enables aberrant dentate network activity.

Hendricks, William D; Westbrook, Gary L; Schnell, Eric

Hendricks, William D; Westbrook, Gary L; Schnell, Eric.

Affiliation

Hendricks WD; Neuroscience Graduate Program, Vollum Institute, Oregon Health & Science University, Portland, OR 97239.
Westbrook GL; Department of Anesthesiology and Perioperative Medicine; Oregon Health & Science University, Portland, OR 97239.
Schnell E; Vollum Institute, Oregon Health & Science University, Portland, OR 97239.

Proc Natl Acad Sci U S A ; 116(22): 10994-10999, 2019 05 28.

Article in En | MEDLINE | ID: mdl-31085654

Subject(s)

Dentate Gyrus/physiopathology; Epilepsy/physiopathology; Mossy Fibers, Hippocampal; Adenosine/metabolism; Adenosine/pharmacology; Animals; CA3 Region, Hippocampal/physiopathology; Disease Models, Animal; Male; Mice; Mice, Transgenic; Mossy Fibers, Hippocampal/drug effects; Mossy Fibers, Hippocampal/metabolism; Mossy Fibers, Hippocampal/physiopathology; Optogenetics; Synapses/metabolism

Key words

adenosine; epilepsy; mossy fiber; seizure; sprouting

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dentate Gyrus / Mossy Fibers, Hippocampal / Epilepsy Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Document type: Article

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