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Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.
Llabani, Evijola; Hicklin, Robert W; Lee, Hyang Yeon; Motika, Stephen E; Crawford, Lisa A; Weerapana, Eranthie; Hergenrother, Paul J.
Affiliation
  • Llabani E; Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL, USA.
  • Hicklin RW; Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL, USA.
  • Lee HY; Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL, USA.
  • Motika SE; Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL, USA.
  • Crawford LA; Department of Chemistry, Boston College, Chestnut Hill, MA, USA.
  • Weerapana E; Department of Chemistry, Boston College, Chestnut Hill, MA, USA.
  • Hergenrother PJ; Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL, USA. hergenro@illinois.edu.
Nat Chem ; 11(6): 521-532, 2019 06.
Article in En | MEDLINE | ID: mdl-31086302
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Thioredoxins / Cell Death / Diterpenes / Azulenes / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Thioredoxins / Cell Death / Diterpenes / Azulenes / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Chem Journal subject: QUIMICA Year: 2019 Document type: Article Affiliation country: United States Country of publication: United kingdom