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The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?
Gekara, Nelson O; Jiang, Hui.
Affiliation
  • Gekara NO; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University,106 91 Stockholm, Sweden. nelson.gekara@su.se.
  • Jiang H; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, 90 187, Umeå, Sweden.
Sci Signal ; 12(581)2019 05 14.
Article in En | MEDLINE | ID: mdl-31088977
ABSTRACT
Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Signal Transduction / Immunity, Innate / Nucleotides, Cyclic / Nucleotidyltransferases Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: Sweden
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Signal Transduction / Immunity, Innate / Nucleotides, Cyclic / Nucleotidyltransferases Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2019 Document type: Article Affiliation country: Sweden